This product is a box of 10 vials.
What Is Triptorelin Acetate ?
Triptorelin is a synthetic version of gonadotropin-releasing hormone (GnRH) that has been used in medical settings to treat advanced prostate cancer. It is part of a broader approach to reduce male hormones. Like luteinizing hormone-releasing hormone, triptorelin strongly blocks the production of testosterone and estrogen when given continuously over a long period. In the UK, triptorelin is used to lower testosterone and estrogen levels in transgender people. The peptide has also been applied to treat hormone-sensitive breast cancer in women before menopause.
Sequence: Pyr-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly
Molecular Formula: C66H86N18O15
Molecular Weight: 1371.5 g/mol
PubChem CID: 25080282
CAS Number: 140194-24-7
Synonyms: Decapeptyl, TRP(6)-LHRH, Trelstar, Triptoreline, Decapeptyl, Gonapeptyl
Restores Testosterone Levels in Some Men
The way triptorelin is used can greatly change its effects. Studies show that triptorelin raises testosterone levels early in long-term treatment and only starts to lower production after ongoing exposure. This is called testosterone flare and happens in the first few weeks of treatment. This suggests triptorelin might help boost testosterone in some men if given at the right time and dose.
Dosing Determines Effects
Triptorelin mimics gonadotropin-releasing hormone (GnRH). It can stimulate the front part of the pituitary gland to release follicle-stimulating hormone (FSH) and luteinizing hormone (LH). If given in short bursts, this is what triptorelin does. The exact amounts of FSH and LH depend on the dose size and how often it is given. But if triptorelin is given steadily instead of in bursts, it will eventually lower LH and FSH release, as well as testosterone and estrogen production. How triptorelin is given in studies decides its final effects.
Most research on triptorelin focuses on long-term use to lower sex hormone levels. This work mainly targets cancer and how sex hormones affect tumor growth. Lately, there is interest in using triptorelin to restore sexual function, fertility, and testosterone levels, but the research is still early.
Breast Cancer
A key part of modern breast cancer treatment is to suppress hormones for cancers that respond to them. Tamoxifen is the most common drug for this now. It is a selective estrogen receptor modulator (SERM) used to treat and prevent cancer in some patients. Tamoxifen cuts the risk of breast cancer returning by about 40-50% in women after menopause and by 30-50% in women before menopause. It has also been used to shrink tumors before surgery. While tamoxifen works well, it has side effects, and tumors can become resistant over time. The search for other options or add-ons to tamoxifen has led to studies on triptorelin in breast cancer.
A recent phase 3 clinical trial showed that triptorelin, when used with zoledronic acid or letrozole, works better than tamoxifen at improving 5-year survival without disease in women before menopause. Similar studies found that adding triptorelin to tamoxifen for early-stage breast cancer helps control the disease and boosts survival, especially in high-risk patients after chemotherapy. The ability to improve hormone therapy and extend its benefits has made this area of triptorelin research very active.
Prostate Cancer Treatment
Triptorelin's main use is in prostate cancer treatment, where it slows growth by lowering testosterone. For hormone-sensitive prostate cancer, triptorelin drops the 10-year death rate to under 5%. It also reduces the need for surgery. Overall, triptorelin lets most men live out their lives despite prostate cancer. Still, there is interest in combining it with other treatments to extend benefits.
New studies show that pairing triptorelin with radiation therapy can match the results of full hormone blockade. This might seem small, but full blockade has side effects many men find hard to handle. Cutting side effects while keeping results strong can improve life quality and treatment follow-through.
Research also shows triptorelin can ease lower urinary tract symptoms in men with prostate cancer, dropping severe weekly symptoms from nearly 54% to 12%. These findings have been confirmed in trials in China, Belgium, South Korea, and elsewhere. This suggests triptorelin might help with benign prostate enlargement and other issues affecting urination in men. At least, it relieves one of the toughest symptoms of prostate cancer.
Protects Fertility
Chemotherapy often causes fertility loss, especially in younger people. A small trial of triptorelin in young women on chemotherapy showed it preserves fertility in many patients. Similar work found triptorelin can cut early menopause after chemotherapy by about 17%.
Triptorelin aids fertility in many patients beyond chemotherapy. Studies in women with adenomyosis show triptorelin raises natural pregnancy rates and improves the condition itself. Similar benefits appear in women with endometriosis.
Not Linked to Alzheimer's Disease
Being female raises Alzheimer's disease (AD) risk. Studies suggest testosterone protects against AD, while estrogen and progesterone may increase risk. There was worry that lowering male hormones could raise AD risk in men, and early data seemed to agree. Later research shows those studies were too simple, and hormone reduction likely isn't the cause. A large review of FDA adverse event data does not link triptorelin to AD or thinking problems. Experts think prostate cancer's effects, like stress from diagnosis on mood and habits, may play a bigger role in AD than hormone therapy. The issue isn't settled, but evidence points away from hormone reduction to other causes.
Endometriosis
Studies show triptorelin reduces pain in endometriosis by shrinking nodule size. This might make it a good pre-surgery treatment to cut bleeding and other issues in endometriosis operations. Early research suggests triptorelin improves laparoscopic surgery outcomes for endometriosis, especially raising pregnancy rates after surgery.
Triptorelin has strong effects in women with colorectal endometriosis, cutting pain in nearly 80% and diarrhea in about 60%. The trial was just three months; longer use might improve results. Triptorelin doesn't cure endometriosis but makes it manageable. Future studies may find ways to cure it permanently with the peptide.
Immune Function
Rat studies show LHRH directly affects the thymus, a key immune system part. Aging reduces LHRH binding sites on the thymus, leading to a 50% drop in thymic size over time. This causes age-related immune issues, like more colds and flu. Giving an LHRH mimic like triptorelin boosts thymus growth and partly reverses aging effects. There is thought that triptorelin might prevent age-related thymus changes and improve immune performance. It could be used to treat or prevent issues.
The Problem
Mainstream PCT usually involves brief HCG and/or HMG use followed by SERMs like Tamoxifen and Clomiphene (goal = restore endogenous testosterone and sperm production in the testes).
Sometimes, a user will find the effect of HCG/HMG to be insufficient for a timely HGPA restart, because the pituitary gland (which normally makes HCG/HMG, in the form of LH/FSH) has also been "asleep" for quite some time).
One could in theory stay on HCG/HMG indefinitely, but this is contrary to many people's goals when "coming off" (not to mention, quite a pain in the ass).
Why Triptorelin?
What if we could send a signal to actually wake the pituitary up? Normally, the hypothalamus produces GNrH, which does exactly this.
An extremely small and short-acting dose of Triptorelin will effectively replace this signal, signalling the pituitary to turn back on. If it's small enough, it won't shut down the hypothalamus or down-regulate the pituitary GNrH receptors.
Dosing
Please read the DOSING & ADMINISTRATION TAB (above) for instructions on how to take this!
MORE DOES NOT EQUAL BETTER
Did you know that one of Triptorelin's clinical uses is monthly chemical castration for sex offenders? Of course, the dose is much higher -- so high it basically burns out and desensitizes the system. Scientifically, the pituitary's GNrH receptors down-regulate in response to the excess Triptorelin, and thus become much less responsive to not only Triptorelin, but any GNrH your hypothalamus makes. This causes the pituitary to stop secreting most if not all LH/FSH, resulting in a total crash in sperm and testosterone production.
TWO TYPES OF TRIPTORELIN
Triptorelin is commonly found in two different forms:
Triptorelin Acetate:
The Acetate salt has a shorter half-life in the body, and is commonly found in 2 and 5mg vials. We recommend and thus stock and sell this salt.
Triptorelin Pamoate:
The Pamoate salt has a longer half-life, and comes in 3.75mg vials. Less ideal for PCT.
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