This product is a box of 10 vials.
What Is Selank ?
Selank peptide is a short, synthetic version of tuftsin. It has strong anti-anxiety effects. Selank also improves memory and learning, and it has shown positive effects on how pain is felt.
Selank is a short, synthetic version of tuftsin. It has strong anti-anxiety effects. Selank also improves memory and learning, and it has shown positive effects on how pain is felt.
Sequence: Thr-Lys-Pro-Arg-Pro-Gly-Pro
Molecular Formula: C33H57N11O9
Molecular Weight: 751.87 g/mol
CAS Number: 129954-34-3
Synonyms: Selanc
Anxiety Effects Based on Genes Related to GABA
According to Dr. Anastasiya Volkova of the Institute of Molecular Genetics in Russia, many clinical studies have shown that Selank has strong anti-anxiety and brain-protecting effects in treating anxiety. The clinical effects of Selank are similar to those of classic anti-anxiety drugs like benzodiazepines, which adjust GABAA receptors and boost the calming action of GABA. Selank’s effects include lowering anxiety, improving mood, reducing stress, and positively affecting memory and learning. At low doses, Selank has a calming effect. Unlike benzodiazepines, Selank does not seem to cause addiction, withdrawal symptoms, or memory loss.
Research in rats shows that out of 84 genes linked to GABA signaling, seven are strongly changed by Selank, and 45 show some shift in activity when the peptide is given. In total, 52 genes tied to GABA signaling are affected by Selank to some extent. These findings suggest that Selank can directly influence how genes are expressed in nerve cells, likely by altering how well GABA receptors bind to GABA. This change in receptor binding probably explains why Selank works well alongside benzodiazepines and other drugs that target GABA receptors.
Studies in rats show that Selank and benzodiazepines, when used alone, have similar effects on anxiety, especially generalized anxiety disorder. Selank might have a small edge over benzodiazepines in lowering high anxiety levels, but combining the two seems best for handling unpredictable ongoing mild stress.
Selank's impact on GABA receptors might be partly influenced by how the peptide affects enkephalin breakdown. Tests show that people with anxiety and phobic disorders have higher enkephalinase activity in their blood during generalized anxiety, causing their enkephalins to break down faster. By stopping enkephalin breakdown through blocking enkephalinase, Selank may reset this pathway and help protect the body's natural anxiety-relieving peptides. Studies in anxiety-prone mice support the idea that at least some of Selank's effects come from preventing enkephalin breakdown.
Immune System + Anxiety
Research in people with depression shows that Selank can reduce the gene that makes the inflammatory protein IL-6. Interestingly, this only happens in those with depression and not in healthy people. This suggests Selank could help treat people with anxiety-asthenic disorders, which are serious conditions where anxiety comes with fatigue, headaches, heart palpitations, high blood pressure, nerve pain, and depression.
When comparing Selank to standard anxiety treatments like benzodiazepines, both reduce anxiety similarly, but only Selank helps with asthenic symptoms like fatigue and pain. Part of this is likely due to Selank's ability to adjust IL-6 levels, while another part comes from how it slows the breakdown of the body's natural pain relievers, enkephalins.
Testing of Selank in rats has shown that the peptide controls the activity of about 34 genes involved in inflammation. These genes affect chemokines, cytokines, and their receptors. In particular, Selank changes the activity of Bcl6, a gene that's key in immune system development. More than any other study, this one highlights Selank's complex biological effects and how it might improve our understanding of immune system growth.
Selank and even parts of Selank have been shown to temporarily change gene activity for C3, Casp1, Il2rg, and Xcr1 in the mouse spleen. By affecting these genes, Selank can shift the immune system's balance and help control inflammation.
Memory and Learning
There's a long-known link between anxiety and memory or learning, where more anxiety means it's harder to remember things or learn new information. Traditional anxiety treatments can lessen this problem, and so can Selank. But Selank seems to do more than just ease anxiety's impact on thinking—it appears to directly improve brain function.
In studies with rats trained using food rewards and given either saltwater or Selank, the peptide improved memory stability, making it easier to store memories. Importantly, this benefit appeared no matter the rats' anxiety levels, showing the peptide has effects beyond just reducing stress-related memory issues.
It seems Selank may change memory by affecting gene activity in the hippocampus. Research in rats shows shifts in mRNA levels for 36 different genes after Selank is given through the nose. Most of these genes code for proteins linked to the cell membrane and could adjust ion-related processes in learning and memory. Though more research is needed to figure out exactly how Selank boosts memory and learning, this early finding hints that it changes how neurons work, making it simpler to form and retrieve memories.
Studies even suggest Selank can help restore memory and learning after brain damage. In at least one study, rats given a neurotoxin and then Selank recovered their thinking abilities. This seems tied to Selank artificially slowing the catecholamine system in the brain. There's hope that Selank could shed light on improving or restoring brain function after traumatic brain injury, especially injuries from birth.
Pain
Selank may help reduce the breakdown of natural enkephalins by blocking the enzymes in human blood that destroy them. Enkephalins are natural peptides that bind to opioid receptors and dull pain. They also play a role in the human stress response and are abundant in the brain and adrenal glands. By lowering enkephalin levels in the brain, Selank might soften the usual stress response and its effects on memory, learning, and focus.
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