This product is a box of 10 vials.
BENEFITS:
- Improve sex drive and desire by stimulation of hypothalamus
- Reduces belly fat through lipolysis
- Increases energy and vitality
- Improves skin elasticity, ridding wrinkles
- Increases endurance
- Accelerates healing from wounds or surgery
- Strengthens the heart
- Enhances the immune system
- Increases IGF-1 production, by as much as 50% in first week
- Improves sleep patterns
- Improves eyesight and vision
- Increases calcium retention, strengthens and increases the mineralization of bone, bone density
- Increases protein synthesis
Dosage & administration:
- Half life
- 2 hours
- Dosage
- 150-300mcg 3 or 4 times daily. One injection upon waking, once before training, one prior to the evening meal and the final injection immediately before bed time is optimal dosing.
- Average Cycle Length
- Indefinite and ongoing since no user limit or cycle limit has ever been established.
What Is Ipamorelin ?
Ipamorelin is a short peptide sequence that can bind to the ghrelin/growth hormone secretagogue receptor. It is one of the most selective growth hormone (GH) secretagogues known and has been shown in lab studies to have no effect on ACTH, prolactin, follicle-stimulating hormone, luteinizing hormone, thyroid-stimulating hormone, or cortisol release. Given its high level of specificity, ipamorelin has been of interest in research both as a treatment on its own and as a model peptide for understanding how selectivity in GH receptor binding is achieved. Its presence plays a key role in the overall growth and repair of muscle and bone tissue.
Sequence: Aib-His-D-2-Nal-D-Phe-Lys-NH2
Molecular formula: C38H49N9O5
Molar Mass: 711.85296
CAS number: 170851-70-4
PubChem: CID 20754357
Synonyms: Ipamorelin Acetate, IPAM, NNC-26-0161
Negative Corticosteroid Effects
Glucocorticoids are a type of corticosteroid often used to treat inflammation in conditions from cancer to autoimmune diseases. They have many serious side effects that can limit how useful they are. Reducing these side effects could allow for higher doses and longer use, which might improve health outcomes and reduce death rates. Ipamorelin has been shown in several studies to lessen or even reverse the side effects of glucocorticoid use.
Bone Health
One of the biggest problems with long-term glucocorticoid use is loss of bone density and higher risk of fractures. Current treatments include bisphosphonates, hormone therapies, and new monoclonal antibodies. All of these work well but have their own side effects, limited results, or high costs. Ipamorelin is fairly cheap to make and has few side effects. Studies in rats show that ipamorelin can fully stop bone loss caused by corticosteroids and even lead to a four-fold increase in bone formation in rats given these drugs. Further studies show that ipamorelin also boosts bone mineral density throughout the body, strengthening both existing and new bone. As an extra benefit, ipamorelin helps counter other steroid side effects, like muscle wasting and more belly fat.
Muscle Growth
There is evidence that GH and growth hormone secretagogues like ipamorelin may reduce the muscle-breaking effects of glucocorticoids. Research in rats given glucocorticoids shows a drop in nitrogen loss in the liver and better nitrogen balance after ipamorelin. Muscle wasting is a main side effect of glucocorticoid use and often limits treatment. Being able to fight muscle breakdown and bone loss with one drug could greatly help patients who need glucocorticoids.
Diabetes
Research in diabetic rats has shown that ipamorelin can strengthen insulin release. This effect likely comes from indirect stimulation of the calcium channel on pancreatic islet cells where insulin is produced and stored. Ipamorelin's actions on the pancreas may help us better understand the limits of type 2 diabetes and lead to new treatments or even ways to prevent it.
Treatment of Post-Operative Ileus
Post-operative ileus (POI) is a common issue after certain surgeries, especially abdominal ones. It means people can't eat by mouth because the digestive system stops working. It can cause pain, but the main problem is that it slows hospital discharge and recovery time.
Ipamorelin has been tested in early clinical trials to see if it can shorten POI. The research suggests ipamorelin can reduce time to the first meal by about 12 hours. Unfortunately, the trials were stopped when the company decided the results weren't strong enough for a product. There is hope that more research can improve results or that combining ipamorelin with other treatments can create a stronger effect.
1. The amount of radiolabeled food left in the stomach is lower in rats with POI after ipamorelin, even compared to rats without POI.
2. The location of the food is similar to rats without POI when rats with POI get ipamorelin.
3. The food's location is farther along in the digestive tract, similar to rats without POI, after ipamorelin.
Ghrelin Receptor Probe
Ipamorelin is a selective ghrelin receptor activator and binds strongly to it. The ghrelin receptor increases in certain cancers (like human carcinomas) and heart failure. Researchers recently suggested ipamorelin could be used as a probe in positron emission tomography (PET) to help with diagnosis. Basic lab tests have shown this idea works and confirmed that ipamorelin, which is easy to make in a lab, could be used as a PET probe. The next step is to test it in living subjects and create standards for reading PET scans done with it.
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