This product is a box of 10 vials.
Dosage & administration:
- Half life
- 30 hours
- Dosage
- 500mcg a day before ongoing until desired skin tone is achieved
- Bioavailability
- 100%
- Average Cycle Length
- Indefinite and ongoing daily dosing required to reach desired skin tone and then 500mcg every other day to maintain skin tone
What Is Melanotan 2 (MT-2)Â ?
Melanotan-2 (MT-2) is a man-made peptide that mimics α-MSH, a hormone found in humans. Created at the University of Arizona in the 1980s, it was initially designed for sunless tanning due to its ability to darken skin. Over time, researchers found MT-2 has broader effects, including:
- Increasing sexual arousal
- Promoting skin tanning
- Reducing compulsive behavior
- Helping control addiction
- Decreasing hunger
- Lowering glucagon production
- Potentially reversing autism features
Peptide Sequence: Nle-Asp(1)-His-D-Phe-Arg-Trp-Lys(1)
Molecular Formula: C50H69N15O9
Molecular Weight: 1024.198 g/mol
PubChem CID: 92432
CAS Number: 121062-08-6
Melanocortin Receptors
Melanotan-2 works by binding to melanocortin receptors, which have different roles in the body. There are five known receptors, and MT-2 primarily interacts with:
- MC-1R: Found on melanocytes, it triggers skin and hair darkening.
- MC-3R: Linked to appetite and energy regulation, though less understood.
- MC-4R: Affects feeding behavior, sexual function, and energy balance.
It also weakly binds to MC-3R and has minor effects on MC-2R (adrenal hormone production) and MC-5R (sweat glands and pancreatic cells).
Autism
Recent studies suggest MT-2 may reduce autistic traits in a mouse model of autism spectrum disorder (ASD) caused by maternal immune activation. There’s no cure for ASD, but therapies like oxytocin show promise. MT-2, which boosts oxytocin release, improved communication, social interaction, and repetitive behaviors in these mice. It also increased oxytocin receptor levels in specific brain areas, indicating a link between oxytocin signaling and ASD behaviors. This could lead to new treatments and a better understanding of ASD’s brain pathways.
Hunger and Food Preferences
MT-2 reduces hunger and fat storage in animals by acting on the melanocortin-4 receptor (MC-4R). In mice, it lowered food intake and shifted preferences away from fatty foods. Mice without MC-4R ignored MT-2’s effects and preferred fatty foods. MT-2’s actions are similar to leptin, a hormone that reduces cravings, but MT-2 works through both leptin-dependent and leptin-independent pathways, making it potentially more effective for appetite control. It also increases expression of a brain hormone (TRH) tied to satiety, which leptin alone struggles to do effectively.
Diabetes
Diabetes involves high blood sugar, excessive glucagon, and ketone production. Leptin helps counter these by improving glucose uptake and reducing glucagon and ketone formation, but it doesn’t easily reach the brain. MT-2, which crosses the blood-brain barrier more effectively, mimics these effects through melanocortin receptors. This makes MT-2 a potential alternative for managing diabetes without relying solely on insulin.
Impulse Control and Alcohol Use
MT-2 may influence impulse control via the MC-4R receptor. In rats, it reduced alcohol consumption and increased water intake, even in those that preferred alcohol. When combined with naltrexone, MT-2 was over seven times more effective at reducing binge-like alcohol intake in mice. This suggests MT-2 could help treat alcohol-related disorders and provide insights into craving, desire, and motivation in areas like addiction, work, or relationships.
Erectile Dysfunction
While drugs like sildenafil (Viagra) treat erectile dysfunction (ED) caused by blood flow issues, they don’t work for everyone, especially those with non-vascular ED or women with low sexual desire. MT-2, acting on the central nervous system, is effective for both men and women. In a study of men who didn’t respond to Viagra, 80% showed improvement with MT-2, highlighting its potential for treating sexual desire disorders.
Curious about MT-2 (Melanotan)?
Join our Facebook group to engage directly with thousands of others who use this product, and follow our Facebook/IG pages for hot updates and product announcements!