MT-2 (Melanotan)

Melanotan is a type of peptide called a melanotropin peptide which is an analog of the alpha-melanocyte stimulating hormone. This peptide is created and circulated within the skin. Synthetic Melanotan 2 is designed to tan and darken skin.

Melanotan 2 is a smaller and more potent than melanotan 1,it targets more melanocortin receptors. This new peptide has a protective ring of amino acids which further separates it from the linear style peptide of melanotan 1, which ensures better absorption. Melanotan II is in a class of peptide hormone known as Melanocortins (MCs). Melanocortins (MCs) are multifunctional peptide hormones that regulate a diversity of physiological functions. MCs have been implicated in sexual function in animals. It is a cyclic lactam analog of -MSH with the amino acid sequence Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2.

Because of its effect on fat loss, tanning peptide is also used to aid in weight loss. Since the melanocortin system is important for controlling body weight, the use of melanotan increases oxidation in fatty acids which improves insulin sensitivity, requiring less food to feel full and helps the body flush out fats. There are many who make use of melanotan: fitness enthusiasts and bodybuilders along with some athletes tend to use these types of peptides in order to increase the efficiency of their training regimen. This is because of the melanotans ability to store energy within cells for easy access by the body, making it easier for the body to use them during training.

Because melanotan treatments are so effective (around 1,000 times more potent than naturally occurring melanotropin), many people think that they can begin a melanotan therapy and will be immune to the harmful effects of the sun. Those with blonde or red hair, especially those who are very pale should be careful and protect themselves with sunglasses, sunscreen and basic protections when going out in the sun for extended periods of time. Melanotan requires a bit of patience but users will see dramatic results in longer time.

Melanotan comes freeze dried and sealed in a multi-use sterile vile which is injected under the skin where it binds to melanocortin receptors. These receptors influence things like pigmentation, appetite, skin inflammation, and sexual function. For practical purposes, this means that those that have fair skin, can achieve a rich, natural-looking tan even if they have an allergy to sunlight. This also means that these peptides make one of the best defenses against skin cancer available, all without spending years trying to develop a tan that will protect the skin.

When taking melanotan to darken the skin, it’s important to remember that the tanning effect is a side effect of the peptide. When UV damage occurs in cells, the body responds by dispatching cells to repair this damage which then tan to protect the skin from further damage. This means that the users body is not growing darker but is in fact tanning naturally with help from the peptide.

EACH VIAL CONTAINS:
Melanotan II (MT2) BP 10mg
Peptides ship in a lyophilized (freeze-dried powder) form for maximum stability.
BAC water not included.
Ships with an express courier such as FedEx, DHL, or UPS.
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$299.99

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This product is a box of 10 vials.

Dosage & administration:

Half life
30 hours
Dosage
500mcg a day before ongoing until desired skin tone is achieved
Bioavailability
100%
Average Cycle Length
Indefinite and ongoing daily dosing required to reach desired skin tone and then 500mcg every other day to maintain skin tone

What Is Melanotan 2 (MT-2) ?

Melanotan-2 (MT-2) is a man-made peptide that mimics α-MSH, a hormone found in humans. Created at the University of Arizona in the 1980s, it was initially designed for sunless tanning due to its ability to darken skin. Over time, researchers found MT-2 has broader effects, including:
- Increasing sexual arousal
- Promoting skin tanning
- Reducing compulsive behavior
- Helping control addiction
- Decreasing hunger
- Lowering glucagon production
- Potentially reversing autism features

mt2

Peptide Sequence: Nle-Asp(1)-His-D-Phe-Arg-Trp-Lys(1)
Molecular Formula: C50H69N15O9
Molecular Weight: 1024.198 g/mol
PubChem CID: 92432
CAS Number: 121062-08-6

Melanocortin Receptors

Melanotan-2 works by binding to melanocortin receptors, which have different roles in the body. There are five known receptors, and MT-2 primarily interacts with:
- MC-1R: Found on melanocytes, it triggers skin and hair darkening.
- MC-3R: Linked to appetite and energy regulation, though less understood.
- MC-4R: Affects feeding behavior, sexual function, and energy balance.
It also weakly binds to MC-3R and has minor effects on MC-2R (adrenal hormone production) and MC-5R (sweat glands and pancreatic cells).

Autism

Recent studies suggest MT-2 may reduce autistic traits in a mouse model of autism spectrum disorder (ASD) caused by maternal immune activation. There’s no cure for ASD, but therapies like oxytocin show promise. MT-2, which boosts oxytocin release, improved communication, social interaction, and repetitive behaviors in these mice. It also increased oxytocin receptor levels in specific brain areas, indicating a link between oxytocin signaling and ASD behaviors. This could lead to new treatments and a better understanding of ASD’s brain pathways.

Hunger and Food Preferences

MT-2 reduces hunger and fat storage in animals by acting on the melanocortin-4 receptor (MC-4R). In mice, it lowered food intake and shifted preferences away from fatty foods. Mice without MC-4R ignored MT-2’s effects and preferred fatty foods. MT-2’s actions are similar to leptin, a hormone that reduces cravings, but MT-2 works through both leptin-dependent and leptin-independent pathways, making it potentially more effective for appetite control. It also increases expression of a brain hormone (TRH) tied to satiety, which leptin alone struggles to do effectively.

Diabetes

Diabetes involves high blood sugar, excessive glucagon, and ketone production. Leptin helps counter these by improving glucose uptake and reducing glucagon and ketone formation, but it doesn’t easily reach the brain. MT-2, which crosses the blood-brain barrier more effectively, mimics these effects through melanocortin receptors. This makes MT-2 a potential alternative for managing diabetes without relying solely on insulin.

Impulse Control and Alcohol Use

MT-2 may influence impulse control via the MC-4R receptor. In rats, it reduced alcohol consumption and increased water intake, even in those that preferred alcohol. When combined with naltrexone, MT-2 was over seven times more effective at reducing binge-like alcohol intake in mice. This suggests MT-2 could help treat alcohol-related disorders and provide insights into craving, desire, and motivation in areas like addiction, work, or relationships.

Erectile Dysfunction

While drugs like sildenafil (Viagra) treat erectile dysfunction (ED) caused by blood flow issues, they don’t work for everyone, especially those with non-vascular ED or women with low sexual desire. MT-2, acting on the central nervous system, is effective for both men and women. In a study of men who didn’t respond to Viagra, 80% showed improvement with MT-2, highlighting its potential for treating sexual desire disorders.

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