This product is a box of 10 vials.
- Half life
- 30 minutes
- Dosage
- 500mcg 15 minutes before bed
- Average Cycle Length
- Indefinite
- Bioavailability
- Estimated at 100%
What Is DSIPÂ ?
Delta sleep-inducing peptide (DSIP) is a short peptide that occurs naturally. It gets its name from its ability to cause sleep in rabbits and because it was first isolated in 1977 from the brains of rats during slow-wave sleep. However, the peptide has several physiologic and hormone-related roles that researchers are gradually discovering as interest grows. Currently, it is known that DSIP can change levels of corticotropin, block the release of somatostatin, reduce stress, normalize blood pressure, affect sleep patterns, and change how pain is felt. It may also have future uses in treating cancer, depression, and preventing damage from free radicals.
Sequence: Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu
Molecular Formula: C35H48N10O15
Molecular Weight: 848.824 g/mol
PubChem CID: 68816
CAS Number: 62568-57-4
Synonyms: Emideltide, DSIP nonapeptide, Deltaran
Relationship between DSIP & Sleep
Despite its name, the link between DSIP and sleep has been hard to figure out. After the first study in rabbits, DSIP has been thoroughly tested to see its effects on sleep. Unfortunately, a clear pattern has been tough to find. In some studies, DSIP boosted slow-wave sleep and reduced paradoxical sleep. In others, DSIP had no effect on sleep at all. In one study, DSIP caused alertness during the first hour of sleep, followed by calmness starting in the second hour. Overall, this study suggested that DSIP helps normalize sleep and fix problems in sleep cycles, and these effects are generally supported by other research.
Perhaps the most important sleep research on DSIP has focused on chronic insomnia. In this case, the peptide seems to improve sleep enough to match that of people without sleep issues. These results are echoed in other studies showing that DSIP improves sleep structure and shortens the time it takes to fall asleep in chronic insomnia. Overall, studies using sleep monitoring equipment show higher sleep efficiency with DSIP, though the improvement is statistically meaningful but still fairly small.
Despite mixed results in the research, it's hard to deny that DSIP is somehow linked to starting sleep. Studies in people have found several personal reports showing that DSIP promotes sleep. For example, DSIP creates feelings of drowsiness, increases sleep time by 59% compared to a placebo, and shortens the time to fall asleep. However, these personal findings are almost completely contradicted by brain wave tests that show no clear signs of sedation. The issue might be with current testing methods, as many brain wave measures of sedation are based on drug-induced sleep, not natural sleep. At the very least, DSIP provides a new tool for rethinking how we measure sleep in labs. It could help scientists gain a deeper understanding of human sleep, a body function that remains mysterious despite more than a century of focused study.
Chronic Pain
Managing pain can be challenging with chronic pain. Current drugs, like NSAIDs and opioids, work well short-term but can cause serious side effects when used for a long time. These pain relievers are best for brief use, so researchers are looking for alternatives to treat ongoing pain conditions. A small early trial in humans found that DSIP can greatly reduce pain perception and boost mood. This study also suggested that DSIP may help patients who are physically dependent on other pain medications, as it eases withdrawal symptoms and the pain surge that often happens after stopping long-term pain therapy.
Research in rats shows that DSIP works on central opioid receptors in the brain to create its pain-relieving effects. It's not clear if these are direct or indirect effects, but the peptide provides strong pain relief that depends on the dose. There is no sign that DSIP causes the kind of addiction that opioid drugs do, even though both act on the same receptors in the central nervous system.
Metabolism
Studies in rats show that DSIP changes the metabolic disruptions caused by stress, which often make mitochondria switch from using oxygen for energy to not using it. The non-oxygen method is much less efficient and creates harmful byproducts. DSIP's ability to keep oxygen-based energy production going, even in low-oxygen conditions, could make it a useful treatment for issues like stroke and heart attack. By maintaining normal mitochondrial function, DSIP could limit metabolic damage from lack of oxygen and protect tissues until proper blood flow returns.
These features would make DSIP a powerful antioxidant that works at the basic level of free radical creation. By preserving normal mitochondrial function, DSIP lowers free radical production. This might make it a strong anti-aging supplement, but much more research is needed to understand its exact effects.
Depression & Chemical Imbalances
The discovery that DSIP can change mitochondrial activity in low-oxygen settings led scientists to explore how the peptide does this. It turns out DSIP limits changes in monoamine oxidase type A (MAO-A) and serotonin levels. This finding suggested to researchers that the peptide might affect depression.
Analysis of spinal fluid from patients with major depression has shown lower DSIP levels compared to healthy people. Given the strong connection between sleep and depression, it's no surprise that a peptide involved in regulating sleep cycles might also play a role in depression. So far, there has been no effort to treat depression by raising DSIP levels. However, the peptide has been linked to changes in the hypothalamic-pituitary-adrenal axis and may influence suicidal behavior.
Withdrawal and Addiction
Trials testing DSIP's ability to reduce withdrawal symptoms during detox from opioids and alcohol have found that the peptide may offer real benefits. In one study of 107 patients with alcohol or opioid withdrawal symptoms, 97% and 87%, respectively, had complete relief or major improvement. Interestingly, opioid withdrawal was harder to treat, needing more DSIP doses over a longer time. Withdrawal, especially from alcohol, can be life-threatening, so any progress in treating it is important.
Cancer Prevention
Much cancer research aims to cure the disease after diagnosis. A smaller but growing group of researchers focuses on preventing cancer from starting. Most efforts involve boosting the immune system through a cancer vaccine to find and destroy cancerous cells before they spread. However, studies in mice suggest DSIP may prevent cancer better than any vaccine tested so far. In the study, female mice received DSIP for five straight days each month starting at age 3 months until death. Treated mice had a 2.6 times lower rate of tumor development. This big drop in cancer was paired with a 22.6% decrease in chromosome defects in bone marrow.
Cancer Adjuvant
One side effect of chemotherapy is changes in how the central nervous system works. These can include poor motor control, mood changes like depression, and language problems. Children getting chemotherapy are especially at risk for these brain changes after treatment. A recent study suggests DSIP can fix these brain changes or stop them from happening. At least part of this benefit may come from DSIP's targeted effects on brain blood supply. Research in rats shows that DSIP and its variant Deltaran greatly increase blood flow during brain stresses like reduced blood supply or chemotherapy. In an animal model of brain blood shortage, animals given Deltaran survived 100% of the time compared to just 62% without it. By increasing brain blood flow, DSIP can promote healing and reduce metabolic harm.
Physiologic and Muscle-Building Effects
DSIP was first discovered in rabbit brains during slow-wave sleep and has since been tied to sleep and brain regulation of sleep-wake cycles. Interestingly, no one knows where or how DSIP is made. DSIP levels are as high in body tissues outside the brain as in brain tissues, suggesting it might be produced outside the central nervous system and that its main role may not be sleep-related.
There is also a theory that DSIP could be a hypothalamic hormone that controls more than just sleep, similar to how growth hormone affects more than bone and muscle growth. In one study, DSIP blocked somatostatin, a protein in muscle cells that limits muscle growth. By blocking somatostatin, DSIP helps with muscle enlargement and cell increase in skeletal muscle. These direct blocking effects seem strange for a peptide first thought to mainly promote sleep. This has led some scientists to think that research has overlooked DSIP's true purpose and that it might have a broader role in regulating body functions.
Adding to the idea that DSIP is more than a brain peptide, animal studies show it regulates blood pressure, heart rate, body heat production, and the immune system's lymphokine system. Some of these effects appear before any signs of sleep, suggesting DSIP may change body functions to prepare for sleep.
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