Beta blockers are prescribed to block the effects of adrenaline in the body (specifically the heart). For someone who has high blood pressure, an unnaturally fast resting heart rate, or other heart disease, these meds can be lifesavers. For those in the bodybuilding and fitness world, high doses of anabolic compounds, along with vastly increased body mass often spell trouble for the heart long-term.
How does this work?
Most beta blockers block adrenaline EVERYWHERE in the body. Great for the heart, not-so-great for fat burning, terrible for mental acuity, and in some cases bad for sexual performance! Some musicians use propranolol off-label for this reason alone – i.e., to kill off all physical manifestations of stage-fright (without having to go full-Xanax mode). They can still “feel” most of the excitement in their heads, but nervous shaking and sweating? – all gone. We're not musicians though, so propranolol has limited practicality.
Why is Nebivolol Different?
Remember when SARMs hit the market, and bodybuilders found out you can target “just the skeletal muscle”, and leave the brain, balls, and heart alone?
This “receptor selectivity” can be seen in other classes of drugs (e.g. SERMS), and today, we're now seeing it in beta blockers!
In doses less than 10mg, Nebivolol is super-selective for cardiac tissue only! That means none of the brain numbing, none of the fat-loss-blocking, and no crippling sexual sides! If anything, sexual performance is actually BOOSTED -- Nebivolol is the ONLY beta blocker that actually induces nitric oxide production. No it's not going to rock your rocket like Viagra, but on-par or better than arginine for sure. Other than that, most people who take Nebivolol don’t "feel" much of anything. The usual clue that the medicine is working is the drop in their blood pressure and resting heart rate measurements.
Who should not use this?
While Nebivolol will be ideal for many bodybuilders, it isn’t for everyone, and it certainly isn’t a bulletproof replacement for regular cardio and healthy lifestyle. Certain conditions, such as liver and kidney impairment WILL affect your desired dosage, and some conditions (diabetes) may warrant you skipping this drug completely (do your research first please).
Addendum
If you’re seriously into gear and haven’t done so already, we highly recommend establishing a relationship with a cardiologist and/or electrophysiologist (No need to tell them the details of your cycle unless they're cool like that). Quick and painless tests, e.g. echocardiogram /electrocardiogram can show structure, function, and electrical rhythm abnormalities YEARS before they present serious issues down the road. The good news is many issues CAN be managed, improved upon, or even reversed over time. You might not be able to continue slamming 5cc's a week, but it certainly does NOT mean completely giving up on PEDs!
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