What is Tamoxifen and How Does it Work?

A look into the most famous SERM

From Oxandrolone to Equipoise, numerous steroid users have found ways of taking medically-manufactured drugs to their bodybuilding advantage. These medicines have caught the attention of athletes and bodybuilders who are looking for different performance-enhancing alternatives. One such medicine is Tamoxifen, the oldest and most prescribed Selective Estrogen Receptor Modulator (SERM).

Tamoxifen, popularly known as Nolvadex in the steroid industry, is used by many anabolic steroid users even if it is not actually a steroid. This is because it helps prevent estrogen-related side effects brought by some steroids and it works well during post anabolic steroid use. It is one of the most potent and effective of all SERMs in terms of muscle growth and strength improvement.


But what is Tamoxifen originally used for?

Doctors commonly prescribe Tamoxifen to persons diagnosed with a hormone-receptor-positive disease and to treat breast cancer, particularly the early stages. It is also highly-prescribed to stop bone loss after menopause and to lower cholesterol levels.


With that said, how does tamoxifen work to do all these things?

In bodybuilding, tamoxifen acts as both an antagonist and an agonist in relation to the estrogen hormone. It binds to estrogen receptors in certain parts of the body. It does not lower serum estrogen but, instead, binds to the receptors in the chest. Therefore, it prevents estrogen from its original binding point. This process is most valuable to steroid users as an excessive amount of estrogen can bind to the mammary tissue and cause gynecomastia.

Although it blocks estrogen’s action on specific cells, it activates estrogen in liver cells which were found to improve cardiovascular health and lower cholesterol. Liver-related estrogenic activity is most advantageous for bodybuilders as most steroids leave a negative effect on cholesterol levels.

But, perhaps, the most important benefit of Tamoxifen to steroid users is its ability to induce testosterone-stimulating effects. Anabolic steroids usually suppress our natural testosterone production when taken but Tamoxifen, fortunately, speeds it up.

Luckily, Tamoxifen’s popularity has made it easier for steroid users to purchase Nolvadex online. If you’re struggling with estrogen-related side effects during a workout, then this may just be the solution.