This product is a box of 10 vials.
What Is Epithalon ?
Epithalon, also called Epitalon or Epithalamin, is a short synthetic peptide developed in Russia during the 1980s. It stimulates telomerase activity and melatonin production. Studies show it delays age-related changes in the reproductive and immune systems and extends lifespan in mice and rats. While mainly studied for anti-aging, Epithalon also shows promise in treating certain cancers, infectious diseases, and regulating DNA.
Sequence: Ala-Glu-Asp-Gly
Molecular Formula: C14H22N4O9
Molecular Weight: 390.349 g/mol
PubChem CID: 219042
CAS Number: 307297-39-8
Anti-Aging Through Telomerase
Studies on insects and rodents show Epithalon significantly extends life. In healthy fruit flies and rats, it reduces mortality by up to 52%. In mice prone to heart disease and cancer, it increases lifespan by as much as 27% compared to untreated animals. Part of this effect comes from its ability to neutralize free radicals, harmful molecules that damage healthy tissue.
Epithalon also activates telomerase, which protects telomeres. Telomeres are critical for DNA health, and their protection reduces errors in DNA over time. This helps prevent cell damage, aging, and even cancer in some cases.
DNA Activation
Epithalon's impact on longevity goes beyond free radicals and telomeres. It interacts with DNA to turn on specific genes, including those for CD5 and IL-2 (which support immune function), MMP2 (which maintains connective tissue like skin and tendons), and Tram1 (which aids protein production). These effects suggest Epithalon enhances the immune system and the body's ability to heal from injury or daily stress.
In aging rats, Epithalon boosts interferon gamma, a key immune system molecule that helps fight viral infections by activating macrophages, natural killer cells, and T cells.
**Known DNA Interactions of Epithalon:**
- **CD5:** Promotes immune cell development.
- **IL-2:** Increases production of white blood cells.
- **MMP2:** Supports tissue repair and reduces inflammation.
- **Tram1:** Enhances protein production.
- **Arylalkylamine-N-acetyltransferase:** Boosts melatonin production.
- **pCREB:** Regulates circadian rhythm and may reduce tumor growth.
- **Telomerase:** Increases cell longevity.
Skin Health
Epithalon activates the MMP2 gene, which is vital for connective tissues like skin. In rodents, it increases fibroblast activity by 30–45%. Fibroblasts are cells that produce MMP2, collagen, and elastin, which maintain skin structure. This helps speed up healing and slows age-related skin decline. Epithalon also reduces caspase-3 activity, an enzyme tied to cell death, keeping skin cells healthier for longer.
Tumor Growth
In rats with cancer, daily Epithalon treatment slows tumor growth and prevents cancer from spreading to other tissues. It’s being studied as a potential treatment for Her-2/neu-positive breast cancer and may help prevent certain leukemias and testicular cancer. Epithalon also activates the PER1 gene in the hypothalamus, which regulates circadian rhythm and is under-expressed in cancer patients. Boosting PER1 may slow tumor growth and make cancer cells more sensitive to radiation, potentially reducing the radiation doses needed for treatment.
Melatonin and Sleep
Epithalon influences melatonin, a hormone tied to sleep and aging, by affecting proteins that control its production and release. In monkeys, it restores normal melatonin secretion, which supports healthy sleep patterns and may contribute to its anti-aging effects.
Eye Health
In rats with retinitis pigmentosa, a condition that damages the retina, Epithalon improved outcomes in 90% of cases. It helps maintain the eye's normal structure and supports the retina's electrical activity, which is essential for vision.
THE FOUNTAIN OF YOUTH PEPTIDE
Epitalon (also known as Epithalon) is considered the “fountain of youth” peptide. It is a tetra-peptide, which means that it is composed of four amino acid chains. The peptide is used to regulate the cell cycle during telomerase activity. Telomerase, also called telomere terminal transferase, is an enzyme made of protein and RNA subunits that elongates chromosomes. When telomerase activity is not present (when we age), our cells age. Our telomeres get shorter and begin to die off. If telomerase is activated in our cells, our telomeres lengthen, the cell continues to grow and divide, delaying the aging process.
Epitalon’s primary role is to increase the natural production of telomerase, a natural enzyme that helps cells reproduce telomeres, which are the protective parts of our DNA. This allows the replication of our DNA so the body can grow new cells and rejuvenate old ones. Younger people produce a relatively large amount of telomerase and longer telomeres. The longer the telomere strands are, the better cell health and replication they provide. However, as people age, the production of telomerase falls and consequently cell replication and health decline. This is the main reason that people age.It also plays a role in regulating metabolism, increasing the sensitivity of hypothalamus to its natural hormonal influences, normalizing the function of the anterior pituitary and regulating the levels of gonadotropins and melatonin in the body.
Benefits of Epitalon:
As a result of Epitalon’s effect on telomerase production, the benefits are unique and far-reaching and include:
An increase of human lifespan by lengthening telomeres in human cells
Promotion of deeper sleep
Delay and prevention of age-related diseases such as cancer, heart disease, and dementia
Acts as an anti-oxidant by reducing lipid oxidation and ROS (Reactive oxygen species) along with normalizing T cell function.
Improvement of skin health and appearance
Healing of injured and deteriorating muscle cells
Restores and normalizes melatonin levels in older people who have lost some pineal function due to aging
Can increases resistance to emotional stress
Conclusion:
Numerous studies have shown the importance of telomerase production and telomere rejuvenation in fighting the symptoms of aging. As Epitalon has been shown to increase the production of telomerase which in turn strengthens and lengthens telomeres, this means that Epitalon can play a vital role in decreasing the aging process and thus extend human longevity.
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