What is BPC-157?

BPC-157 stands for Body Protection Compound-157, and it's based on the natural body protection compound, or BPC. This protein exists naturally in the human gut. It helps a lot by guarding the digestive tract's lining against harm, aiding in fixes, and supporting the growth of blood vessels.

The man-made version of BPC-157 is a 15-amino-acid chain taken from the bigger BPC protein. It keeps many of the healing traits from the original. Researchers have seen its impact on several areas, including:

- Repairing wounds
- Forming new blood vessels
- The process of blood clotting
- Creating nitric oxide
- How the immune system works
- Gene activity
- Controlling hormones, especially in the gut's nervous system

Sequence: Gly- Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val
Molecular Formula: C₆₂H₉₈N₁₆O₂₂
Molecular Weight: 1419.556 g/mol
PubChem CID: 108101

Wound Healing

In the digestive tract, BPC naturally keeps the protective mucous layer strong to shield deeper tissues from harsh stomach acids, bile, and other substances needed for breaking down food and taking in nutrients. Part of how it does this involves pulling in fibroblasts. BPC-157 affects fibroblasts in a way that depends on the dose, helping them spread faster both in lab dishes and living bodies, which leads to quicker growth and movement. These cells play a central role in mending injuries since they build the foundation proteins outside cells, such as collagen, fibrin, and elastin.

Vascular Growth and Collateralization

BPC-157 strongly promotes new blood vessel formation, speeding up how the cells lining vessels multiply and expand. Rat studies demonstrate that it greatly boosts the development of backup blood routes when blood flow gets blocked. While this shows up most in the gut, signs point to similar help in heart, brain, and muscle areas too. That means BPC-157 could serve as a treatment after events like strokes or heart attacks, and also help scientists explore ways to encourage recovery after low-blood-flow damage. Tests with chicken embryos suggest part of this happens by activating VEGFR2, a receptor on cell surfaces tied to nitric oxide signals. This receptor seems key for the growth, spread, and survival of vessel-lining cells.

Lab work with cells has shown "vascular running" after using BPC-157. This means vessels extend toward injured spots or around blockages to restore flow and keep cells working. Such an ability might lead to oral treatments for gradual artery narrowing, like in heart disease from plaque buildup. In the future, this could reduce the need for operations such as inserting stents or bypassing arteries with grafts.

Tendon Healing

With its effects on drawing fibroblasts and growing vessels, it's no shock that BPC-157 yields good results in animal tests for injuries to tendons, ligaments, bones, and other connecting tissues. These injuries heal slowly, mainly because blood doesn't reach them well. Limited blood means repair cells like fibroblasts arrive late and can't fix as much as needed. Both lab and animal tests on rat tendons show BPC-157 boosts backup vessel growth and raises fibroblast numbers during harm to tendons, ligaments, or bones. Findings suggest it's better than hormones like bFGF, EGF, and VEGF at aiding recovery there.

Special staining tests with FITC-phalloidin reveal that BPC-157 strongly boosts F-actin in fibroblasts. This protein matters for cell shape and movement, playing a big part in how cells shift positions. Further checks with western blotting show BPC-157 increases activity in paxillin and FAK proteins, which are vital for cell movement.

Antioxidant Properties

In rats, BPC-157 neutralizes signs of oxidative stress, such as nitric oxide and malondialdehyde. This highlights its strength as an antioxidant. Other studies back this by showing it lowers reactive oxygen in the gut. Efforts to use modified bacteria like lactococcus lactis to carry BPC-157 into the digestive system found that the bacteria greatly raises peptide levels in cell tests.

Drug Side Effects

Side effects often limit how doctors use medicines. For example, pain relievers like ibuprofen can't be taken long-term due to risks of stomach bleeding or heart issues. Finding ways to block bad effects while keeping the good ones is a major goal in medicine, as it could improve many treatments. BPC-157 counters side effects from pain meds, psychiatric drugs, and some heart treatments.

It's expected that BPC-157 eases gut issues from certain drugs, but surprisingly, it also guards the brain, heart, and other spots. Rat research shows it prevents longer QTc intervals in the heart, which can cause dangerous rhythm problems. Such changes come from meds for diabetes, schizophrenia, and similar issues. In the same way, BPC-157 blocks other harsh effects from mental health drugs, like frozen muscles or messed-up senses. This could help treat mental conditions better, since people often stop meds because of tough side effects.

What does BPC-157 actually do?

Many studies on this one:

Promote tendon and ligament healing by tendon outgrowth, cell survival, and cell migration in a rodent model of Achilles tendon rupture, and also when administered in drinking water to rats with damaged medial collateral ligaments
Tendon-to-bone healing effective enough that they may actually “successfully exchange the present reconstructive surgical methods”
Counter the damaging effects of NSAIDs like ibuprofen or advil on the gut lining so effectively that scientists termed BPC-157 “a NSAIDs antidote” one of which they say that “no other single agent has portrayed a similar array of effects“
Repair the damage from inflammatory bowel disease (IBD) within just days of oral administration in a rodent model of IBD
Help cure perdidontitis when administered in a rodent model of periodontitis, significantly enough to have scientists conclude that “BPC 157 may represent a new peptide candidate in the treatment of periodontal disease“
Reverse systemic corticosteroid-impaired muscle healing, in rodent models where BPC-157 was administered orally once daily for 14 days to rats with crushed gastrocnemius muscle. Similar benefits were demonstrated in a rodent study by Novinscak et al.
Accelerate bone healing in rabbits who suffered segmental bone defect before being treated with BPC-157 .

How much do I take?

BPC-157 and it has been shown to be effective systematically when injected once daily at anywhere from 1-10 micrograms per kilogram of body weight. In most cases, this comes out to a dose of anywhere from 200mcg up to 800mcg. Some folks report the most success dosing twice per day with 250-350mcg for a total of 500-700mcg per day.

One bottle of our BPC-157 contains 5000 micrograms of product (5 milligrams).

How do I take it?

BPC-157 acts systemically. This means that whether you inject it subcutaneously (like you do with HGH or Insulin), intramuscularly (as part of another shot perhaps, OR to get it ultra close to the injury for you super diligent folks), or you simply spray it into your mouth orally, it's gonna work.

We recommend subcutaneous injection for most people as it's just as convenient as pinning HGH or Insulin. Whether you're pinching 'yer belly fat or your kneecap skin (yes you CAN do this, pull that skin up and put the dart in the SKIN, don't be jabbin the bone now), bioavailability is excellent when injected.

If you're gonna squirt it into your mouth, do it SLOWLY, let it it under your tongue for a bit, then swallow. Don't gargle it around like mouthwash k? Bioavailability this way is "moderate" -- not great not terrible.

Under no circumstances should you inject this directly into bone, cartilage, ligaments or tendons. Remember this is a PEPTIDE (messenger), not a trans-dermal filler.

How long should I take it for?

What should I take with it?

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