This product is a box of 10 vials.
Dosage & administration:
- Half life
- 3 hours
- Dosage (General detoxification)
- 600mg/1200mg twice daily for 5 consecutive days
- Dosage (Immediate detoxification and skin whitening)
- 600mg/1200mg every other day for 15 days
- Average Cycle Length
- As required
- Bioavailability
- Estimated at 100%
Glutathione can be administered to the body through various forms such as through glutathione injection, glutathione supplement and glutathione pills, creams and lotions. As an antioxidant, glutathione is made from three amino acid namely glutamic acid, cysteine and glycine elements that are recommended for detoxifying cells.
Glutathione has been discovered as a skin lightening element available in different forms. The main objective for the manufacture of this substance was to cleanse the cells, take off free radicles and boost the bodys immunity. Patients who used glutathione were observed to get a fair light and smooth skin.
However, studies revealed that this element also protects the cells from free radicles responsible for melanin production and skin blemishes. This has made most people to use glutathione in the treatment of skin blemishes such as moles, freckles, uneven skin tone, age spot, skin patches, spots, wrinkles and getting a light skin. Therefore it is the best anti-aging product in the market.
What Is Glutathione ?
Glutathione is a strong antioxidant and regulator of many biochemical processes. It is plentiful in human tissues but decreases with aging. Research shows that glutathione can help reduce neurodegenerative diseases, support cartilage health, prevent age-related eye changes, boost immune function, and keep skin more youthful. Overall, there is strong evidence that glutathione is a powerful anti-aging compound with broad immune and health benefits.
Molecular Formula:Â C10H17N3O6S
Molecular Weight:Â 307.33 g/mol
PubChem CID:Â 124886
CAS No: 70-18-8
Alternative Names:Â Glutathione, Isethion, GSH
Antioxidant
L-Glutathione has long been known as one of the body's key low-molecular-weight antioxidants made by cells. Thanks to the sulfur in its cysteine part, it can remove strong free radicals like peroxides, nitrogen dioxide, HOCl, and many other toxins. It does this through a simple redox reaction, protecting cells, DNA, and parts of the extracellular matrix from free radical damage. Glutathione not only neutralizes free radicals itself but also helps other antioxidants, like vitamins C and E, do their jobs.
Glutathione is found inside cells and as a released substance in the extracellular matrix. It exists in very high amounts in lung tissue, the brain, and the liver. In humans, it is made through a basic redox reaction.
Glutathione is so essential in the body that low levels have been linked to a wide range of diseases, such as diabetes, HIV, cancer, and even tuberculosis. Studies suggest glutathione levels could be a key marker of how severe a disease is and how it progresses. Measuring glutathione might give doctors a better way to assess outlook and decide on treatments and their timing. Even though we know glutathione's role in aging and disease, no standard way to measure and check its levels exists yet. Researchers are exploring how tracking this simple peptide could give key insights into overall health and how well specific treatments work for diseases. In the near future, measuring glutathione might become as common and helpful as checking blood pressure, cholesterol, or blood sugar.
Biological Roles
While best known for its antioxidant work, glutathione plays other roles in the body. It is a key molecule in making leukotrienes (which mediate inflammation) and prostaglandins. This makes it a strong regulator of some immune responses and the inflammation process. It also acts as a cofactor in several biochemical reactions and boosts citrulline's function in the nitric oxide cycle. In short, glutathione is a vital part of cell metabolism and especially important for controlling blood pressure and heart health.
Glutathione is also crucial for proper protein folding in the endoplasmic reticulum. Studies show it helps proteins fold into the right 3D shape to bind to receptors and work normally. It is particularly key in forming disulfide bonds. Though not the only way cells ensure proper protein folding, glutathione is an important part of this cell function and helps cells work correctly.
There is ongoing debate about whether glutathione acts as a neurotransmitter. It certainly adjusts the redox states of things like the NMDA receptor (which would make it a neuromodulator). It also seems to activate ionotropic receptors and the purinergic P2X7 receptor on Muller cells. These cells are in the retina, where they support retinal cell structure and function. This includes controlling neurotransmitter levels. Again, this suggests that even if glutathione isn't a neurotransmitter, it plays a major role in regulating them.
The world’s top expert on glutathione is Dr. Nayan Patel. In 2020, he wrote a book called The Glutathione Revolution, where he talks about the benefits and safety of glutathione supplements. He compares oxidation in the body to rust, a fitting example. Glutathione is the body’s main rust preventer, fighting off all the bad effects of oxidation just like caring for your car prevents rust and its damage. According to Dr. Patel, glutathione levels drop by about 20% after age 40, leading to poorer performance, higher disease risk, and faster aging. The only way to fix this shortfall is through supplements.
Administration
Studies show glutathione isn't well absorbed from food or oral intake. Enzymes in the digestive tract likely break it down before absorption. There is some evidence that curcumin, N-acetyl cysteine, and parts of foods like broccoli and spinach might boost glutathione by providing more building blocks or by speeding up its production.
Unfortunately, there is limited proof that these are the best ways to raise glutathione. While they do increase levels somewhat, their impact seems small mainly because they can't overcome the age-related drop in production ability. Research indicates the only reliable way to greatly change glutathione levels is by injecting it or inhaling it. Dr. Nayan Patel has created a skin-absorbing delivery system for glutathione, but it's not widely used yet.
Aging
Oxidative damage to cells is a major factor in both visible aging signs and processes like cell or tissue aging, hormone changes, metabolic shifts, and DNA damage that cause disease and dysfunction. Given glutathione's role in fighting oxidative damage, it's no surprise it's key to slowing aging effects.
Of course, glutathione itself faces aging effects. As we age, most mammals lose the ability to make glutathione. Luckily, supplements are possible. However, studies show the best forms are injection or nasal inhalation. Injection is the easiest way to give large doses and is most common in research.
Graphs of free radical levels in normal mice versus those prone to Alzheimer’s disease (AD) reveal two things about glutathione. First, they show AD has an oxidative part, meaning at least some risk of AD comes from poor free radical removal in the central nervous system.
Second, they show free radicals rise after glutathione drops. Note that glutathione reduction happens around middle age, with free radical increase following but clear. This pattern holds in humans too. Between ages 30 and 40, glutathione levels start falling. After a 5-10 year delay, free radicals increase. This likely explains many aging aspects that speed up around age 50.
Cancer
With cancer, glutathione seems both helpful and harmful. In treatment, it protects cancer cells from chemotherapy by scavenging toxins like any other. Ongoing work explores if we can selectively lower glutathione in tumor cells to make them more vulnerable to chemo.
Even though oral glutathione supplements aren't very effective, studies suggest they work in some cases. One is preventing skin cancer from UV exposure. Rat studies show oral glutathione greatly reduces skin cancer risk after UV light. This implies that besides sunscreen, taking glutathione orally could help when in the sun. The question is if injecting it would protect even more.
Glutathione's role in cancer is complex because it has both good and bad functions. It's best to see it as helpful in preventing cancer but tricky in treating it. For example, glutathione is key in removing and detoxing carcinogens. This is clearest in smokers' lungs, where glutathione depletes as it removes nitrogen from smoke. Here, supplements can prevent cancer.
But once cancer starts, glutathione can aid tumor growth by removing body toxins meant to kill cancer cells. In short, glutathione's function is complex and depends on context. Scientists are working to use it for best outcomes. What seems clear is that people who avoid carcinogens and live healthy likely gain from glutathione's antioxidant effects.
Brain Effects
Low glutathione levels link to common aging signs and serious issues like neurodegenerative diseases. Glutathione problems play a big, maybe central, role in Parkinson’s disease (PD) onset. New research shows glutathione strongly mediates iron-dependent cell death, or ferroptosis. Without it, this programmed death runs wild in central nervous system cells, causing early aging and neurodegenerative disease. Plenty of studies show supplements with glutathione or its precursors (like N-acetyl cysteine) help offset brain aging.
Glutathione's brain role is clear from its age-related drop. While levels fall body-wide with age due to lower production, the brain drops most sharply. This makes the brain more prone to Parkinson’s and damage after stroke or injury.
The brain glutathione drop is especially critical during stress. Mild stress usually boosts glutathione to protect against worse stress, but aging weakens this. So, as we age, we're more vulnerable to stress-caused neuron damage. Using N-acetyl cysteine supplements helps partly, but the production machinery weakens with age. Thus, studies suggest direct injection or inhalation of glutathione is best to raise levels and prevent stress-related central nervous system damage.
Eye Health
Glutathione's best-known eye role is in the retina, where it acts as an antioxidant and supports Muller cells. These cells in the retina help retinal neuron health and function. Muller cells, or Muller glia, break down acetylcholine and GABA neurotransmitters, guide light to retinal cells, and handle nutrient supply and waste removal for them. They are vital for vision and long-term retina health, protecting against viral infections to diabetic retinopathy.
Glutathione also keeps lens health by maintaining protein thiols reduced, preserving the eye's normal light-scattering. Low glutathione in the lens links to cataracts and lens permeability changes that hinder nutrient exchange.
Studies show glutathione is key for sharp vision and retinal health. With other antioxidants, animal studies show glutathione eye drops reduce eye oxidative stress and slow aging changes like cataracts and vision loss.
Supplements seem to support long-term eye health, including retina, lens, and cornea. Research suggests glutathione may prevent eye diseases and normal aging effects on the eye. Scientists are developing drop-based delivery for the eye, but injected or inhaled glutathione likely benefits the eye too.
Cartilage Health
A main cause of osteoarthritis (wear-and-tear arthritis) is cartilage-maintaining cells failing to adapt to stress. Studies show glutathione plays a key role here. Interestingly, supplements aren't the only way to boost glutathione in cartilage. Cow research shows supplements are just part of healthy cartilage. The other part is resting joints. Best studies show inducing mild oxidant stress, like careful exercise, then resting boosts joint glutathione and slows cartilage aging.
Skin
Studies show glutathione supplements help reduce outward aging signs, especially in skin. A moderate dose over 12 weeks reduces wrinkles, improves elasticity, and lessens photo-aging. It leads to fewer age spots and lighter skin by reducing melanin production. Less melanin likely lowers skin cancer risk too.
Immune System
The immune system is very sensitive to glutathione levels. Interestingly, little evidence shows supplements help in health, but plenty shows big benefits in disease. For example, glutathione or NAC supplements greatly boost immune function in people with HIV.
This strange pattern has led some to say supplementing in health is useless or harmful to immunity. That's not what research shows. Instead, think of it as: Glutathione has no clear effect on healthy immunity but helps in disease, even simple viral ones. So, supplementing is overall good because we can't predict colds, and high glutathione prepares immunity best.
The reason for this behavior likely is the immune system is quiet when healthy but quickly ramps up disease-fighters and antibodies against illness. So, resting immunity needs little antioxidant power. But disease requires huge amounts, so it benefits from high glutathione.
In fact, supplements do seem to raise storage and buffer against disease. A pilot study of liposomal glutathione in humans found it increases stores. This improves natural killer cell function (surveillance cells against disease) and boosts lymphocyte growth. In other words, glutathione supplements in good health prime immunity for strong response to challenges.
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