What is SLU-PP-332?
SLU-PP-332 is a lab-made compound that some scientists think could help with skin health, muscle repair, and reducing inflammation. It was created in the early 2000s at Saint Louis University (that’s where the “SLU” comes from).
It’s not a peptide (despite what some say)—it’s a small synthetic molecule that turns on a protein in your cells called ERRα (estrogen-related receptor alpha). It does this very strongly, with a score called EC50 of 98 nM.
Think of it like a key that fits into a specific lock in your cells to boost energy, fat burning, and cell repair—without acting like estrogen.
How Does It Work?
SLU-PP-332 mainly works by:
- Boosting mitochondria (your cells’ power plants)
- Improving how your body uses fat and sugar for energy
- Helping control inflammation
- Supporting tissue repair (like skin and muscle). It does this by attaching to ERRα and teaming up with a helper protein called PGC-1α, which turns on genes for energy and repair.
Possible Benefits (Based on Early Research)
1. Skin Health & Anti-Aging
- May help skin cells make more collagen (keeps skin firm and smooth)
- Could speed up wound healing
- Might reduce wrinkles and fine lines over time
Note: Most evidence is from lab or animal studies—not humans yet.
2. Muscle Repair & Recovery
- May wake up “satellite cells” that fix damaged muscle
- Could reduce soreness after workouts
- Might help muscles recover faster from injury or exercise
Still early-stage research—no big human trials yet.
3. Reducing Inflammation
- May lower levels of inflammatory signals like IL-6 and TNF-α
- Could help calm overactive immune responses
- Might be useful one day for conditions like arthritis (but not proven)
4. Antioxidant Effects
- Possibly helps fight cell damage from free radicals
- May support the body’s natural cleanup systems
Not confirmed in humans—needs more study.
5. Metabolic Health (Exercise in a Pill?)
- Acts like exercise by improving fat burning and energy use
- Early studies suggest it could help with blood sugar control or weight management
- Not a magic pill—but exciting for future treatments
Why Should You Care?
SLU-PP-332 is being studied as an “exercise mimetic”—a compound that gives some benefits of working out, even without moving.
It’s not available for sale and not approved for use. All data comes from:
- Lab tests (in dishes)
- Animal studies
- A few small experiments
No large human trials yet.
Curious about SLU-PP-332?
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