Ibutamoren (MK-677)

Ibutamoren (developmental code names MK 677, MK 0677, L-163,191; former tentative brand name Oratrope) is a potent, long-acting, orally-active, selective, and non-peptide agonist of the ghrelin receptor and a growth hormone secretagogue, mimicking the growth hormone (GH)-stimulating action of the endogenous hormone ghrelin. It has been shown to increase the secretion of several hormones including GH and insulin-like growth factor 1 (IGF-1) and produces sustained increases in the plasma levels of these hormones without affecting cortisol levels.

Mk 677 (Nutrobol) is an orally administrated GH secretagogue originally developed by Reverse Pharmacology. A secretagogue is a term for a substance that chemically signals for the pituitary gland to secrete GH. In other words, MK 677 could be compared to peptides like GHRP-6 or Ipamorelin, only it doesn’t require any injections nor does it have any side effects like GHRP-6. MK 677 was developed in an aim to combat such conditions as muscle wasting, obesity, and osteoporosis. It was also targeted towards the treatment of elderly hip fracture patients, so there are a myriad of studies done on safety.

How it Works: Growth hormone pulse intensity can be increased through 4 possible mechanisms*:

Increasing GHRH (growth hormone releasing hormone) release.
Amplifying GHRH signaling in somatotrophs of the anterior pituitary gland.
Reducing somatostatin release (somatostatin turns off GH release).
Inhibiting of somatostatin receptor signaling.
*Nutrobal (Mk 677) was found to work through all four of these mechanisms. *After ingestion, Growth Hormone (GH) was shown to increase dose-dependently, at doses starting at 5 milligrams (mg) a day. In a study on its effects on catabolic states, a once-daily oral dose of 25mgs was given to healthy young men subjected to short-term diet-induced nitrogen wasting. *After 7 days of this dose, the subjects showed a sustained increase in serum concentration of IGF-1 and Growth Hormone; in addition, the nitrogen wasting was reversed, showing great potential for treatment of conditions involving muscle wasting*.

*Trials testing the effects of this GHS on fighting obesity showed an increase in lean body mass, but neither total nor visceral adipose tissue was effected*. This study gave subjects 25mgs of Nutrobal per day for 8 weeks. The subjects showed an increase in basal metabolic rate after 2 weeks, and an increase in serum levels of GH, IGF-1 and IGF-1 binding protein-3. Increase in lean body mass was hypothesized to be caused by an increase in calorie deposition into the muscle and appetite decrease as opposed to reducing fat storage directly.

A study done for the treatment of osteoporosis and bone mineral density showed some increase in bone density, so there is a true impact on bone mineral density. This can help with injury recovery during your cycle.

Other possible benefits of Nutrobal are associated with improved sleep, improved complexion, increase in energy levels, increase nitrogen retention, increase strength and an improved sense of well being. In addition, some studies also suggest that an increased immune system response was caused by Nutrobal (Mk 677), meaning it boosts the immune system to a degree.[/cs_text][x_feature_headline level=”h5″ looks_like=”h5″ icon=”arrow-right” icon_bg_color=”hsl(0, 100%, 39%)”]How it can help you[/x_feature_headline][cs_text]Elevated growth hormone has literally endless list of benefits to the human body*, why do you think everyone tries to get their hands on HGH? That’s why Nutrobal (Mk 677) is so effective, it increases GH and IGF-1 levels*.

As the studies show, Nutrobal can be used for a number of reasons from growing muscle mass*, to getting shredded*. It does not compete with the levels of growth hormone one can get from exogenously administered HGH, so you can use it with HGH cycles. In fact, by using nutrobal, you can easily get amazing increases of your own natural growth hormone pulses without having to deal with annoying and painful daily HGH injections. It’s like using HGH without having to inject daily.

In a multitude of studies, Nutrobal (Mk 677) increased IGF-1 levels by between 39-89%. To give you an idea of what IGF-1 does, here are some IGF-1 benefits:

Increased Fat Oxidation (fat loss).
Increased Muscle gains (lean mass).
Tightening up loose skin.
Healing old injuries.
Healing Bones, Tendons and Ligaments.
*In fact, many users report growing up to 6 lbs of lean muscle mass in 8 weeks of IGF-1 only cycles*. That’s an amazing result, but injecting IGF-1 daily is painful, costly and frustrating. Now, there is an oral-only alternative.

Dosing: Results have been shown from doses between 5-25mgs a day, dose-dependent results should be expected. Higher doses, over 50mgs, have been reported by some but can be over doing it.

Side Effects: Some of the usual side effects that go with elevated GH levels such as numb hands, some lethargy, as well as slightly increased appetite have been reported with the use of Mk 677.

Interestingly, during prolonged administration, both IGF-1 and GH were increased with no increase in cortisol.