Sibutramine (also known as Reductrim) is a neurotransmitter reuptake inhibitor that reduces the reuptake of serotonin (by 53%), norepinephrine (by 54%), and dopamine (by 16%), thereby increasing the levels of these substances in synaptic clefts and helping enhance satiety; the serotonergic action, in particular, is thought to influence appetite. Older anorectic agents such as amphetamine and fenfluramine force the release of these neurotransmitters rather than affecting their reuptake. Sibutramine is a centrally-acting serotonin-norepinephrine reuptake inhibitor structurally related to amphetamines and as such delivers a pronounced loss in body fat through the modification of food behavioral choices, quite simply put, the craving for carbohydrates is impressively reduced without any real thought by the user.
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|Each capsule contains:|
|60 capsules per sealed pouch/bottle|
Dosage and administration:
Half life: 14 hours
30-90mg per day or as required
Average Cycle Length: Indefinite, studies have shown continuous consumption for upwards of 3 years with no ill effects
Anabolic #: NA
Androgenic #: NA
Oral Bioavailability: Estimated at 97%
CAS Name: (5a,17b)-17-Methyl-2H-androst-2-eno[3,2-c]pyrazol-17-ol
Synonyms: Sibutramine, Reductrim, Trim 30
Sibutramine hydrochloride monohydrate tablets are contraindicated in patients receiving monoamine oxidase inhibitors (MAOIs), patients who have anorexia nervosa and patients taking other centrally acting appetite suppressant drugs.
The use of sibutramine hydrochloride monohydrate capsules in combination with other CNS-active drugs, particularly serotonergic agents, has not been systematically evaluated. Consequently, caution is advised if the concomitant administration of sibutramine hydrochloride monohydrate with other centrally-acting drugs is indicated
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