Cabergoline (brand names Caberlin, Dostinex and Cabaser), an ergot derivative, is a potent dopamine receptor agonist on D receptors. Rat studies show cabergoline has a direct inhibitory effect on pituitary lactotroph cells.It is frequently used as a first-line agent in the management of prolactinomas – due to higher affinity for D receptor sites, less severe side effects, and more convenient dosing schedule than the older bromocriptine. It has at times been used as an adjunct to SSRI antidepressants as there is some evidence that it counteracts certain side effects of those drugs, such as reduced libido and anorgasmia.
It also has been suggested online that it has a possible recreational use in reducing or eliminating the male refractory period, thereby allowing men to experience multiple ejaculatory orgasms in rapid succession, and at least one scientific study supports those speculations. It is also used by bodybuilders to control gynecomastia caused by elevated prolactin levels through the use of anabolic steroids such as nandrolone.